Santa Helena may refer to:

Helena of Constantinople, the mother of Emperor Constantine the Great

Saint Helena, an island in the South Atlantic Ocean

Santa Helena de Goiás, a municipality in Brazil

Santa Helena de Minas, a municipality in Brazil

Santa Helena, Paraná, a municipality in Brazil

Santa Helena, Santa Catarina, a municipality in Brazil

Santa Helena, Maranhão, a municipality in Brazil

Santa Helena del Opón, a town and municipality in Colombia

Grupo Santa Helena, a group of painters

Santa Helena Esporte Clube, a Brazilian football (soccer) club